CLINICAL MANAGEMENT GUIDELINE

Acute infective exacerbation of chronic obstructive airways disease

ICD10: Chronic obstructive pulmonary disease w (acute) exacerbation [J44.1]

Treatment: Empirical antibacterial-Outpatient

It defined as an acute decline in respiratory functions manifested as severely worsening dyspnoea, cough and sputum production from the symptoms baseline. It triggered by an infection, airborne pollutants, and/or other factors (smoking).

Please follow Explicit criteria for hospital admission in exacerbations of chronic obstructive pulmonary disease.


Bacterial infections are a common trigger for acute exacerbation.1 Increased sputum purulence, worsening dyspnoea or increased sputum volume suggest a bacterial infection. 2

Optimize for the local bacterial resistance patterns to the antibiotics.

Treatments

Level 1 / 2
pharmacological
Amoxicillin / Clavulanate
ROUTE
Oral
DOSE
875.000 mg
FREQUENCY
BID
pharmacological
Tetracycline
ROUTE
Oral
DOSE
250.000 mg
FREQUENCY
QID
pharmacological
Doxycycline
ROUTE
Oral
DOSE
100.000 mg
FREQUENCY
BID
pharmacological
Azithromycin
ROUTE
Oral
DOSE
500.000 mg
FREQUENCY
OD

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