CLINICAL MANAGEMENT GUIDELINE

Acute infective exacerbation of chronic obstructive airways disease

ICD10: Chronic obstructive pulmonary disease w (acute) exacerbation [J44.1]

Treatment: Empirical antibacterial-Inpatient

It defined as an acute decline in respiratory functions manifested as severely worsening dyspnoea, cough and sputum production from the symptoms baseline. It triggered by an infection, airborne pollutants, and/or other factors (smoking).

Please follow Explicit criteria for hospital admission in exacerbations of chronic obstructive pulmonary disease.


Indications for hospitalization include:1 -High-risk comorbidities such as pneumonia, heart failure, cardiac arrhythmias, renal failure, liver failure, diabetes -Failed outpatient treatment. -Respiratory distress -difficult to establish oral intake.

  • Signs of respiratory failures.

Treatments

Level 1 / 3
pharmacological
Ceftriaxone
ROUTE
IV
DOSE
1.000 g
FREQUENCY
Q12hr
pharmacological
meropenem
ROUTE
IV
DOSE
1.000 g
FREQUENCY
q8 hr
pharmacological
Piperacillin
ROUTE
IV
DOSE
3.380 g
FREQUENCY
Q6hr
pharmacological
Azithromycin
ROUTE
Oral
DOSE
500.000 mg
FREQUENCY
OD

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  • Weight based dosing
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